In the early 1990s, William Massey of Bell Laboratories (then AT&T, now Lucent Technologies) had an idea for an organization devoted mainly to addressing critical issues involving African-American researchers and graduate students in the mathematical sciences. It was envisioned that this organization would highlight current research by African-American researchers and graduate students in mathematics, strengthen the mathematical sciences by encouraging increased participation of African-Americans and members of other underrepresented groups, facilitate working relations among them, and provide assistance to them in cultivating their careers. This organization became known as the Conference for African-American Researchers in the Mathematical Sciences (CAARMS). For the past twenty years this conference has been held at various institutions and institutes across the U.S. (see caarms.net). The CAARMS 21 program will include invited speakers, tutorials, and a graduate students poster session. While this conference is open to all, it will provide a forum where minority researchers in the mathematical sciences can meet each other and share their work across different mathematical fields.